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Lysine degradation

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
L-lysine + acetyl-CoA <=> H+ + N6-acetyl-L-lysine + CoA 2.3.1
2.3.1.32 lysine N-acetyltransferase


S-adenosyl-L-methionine + protein_N6,N6-dimethyl-L-lysine <=> S-adenosyl-L-homocysteine + Protein_N6,N6,N6-trimethyl-L-lysine 2.1.1.354 [histone H3]-lysine4 N-trimethyltransferase
2.1.1.355 [histone H3]-lysine9 N-trimethyltransferase
2.1.1.356 [histone H3]-lysine27 N-trimethyltransferase
2.1.1.359 [histone H3]-lysine36 N-trimethyltransferase
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
2.1.1.366 [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
2.1.1.372 [histone H4]-lysine20 N-trimethyltransferase
2.1.1.59 [cytochrome c]-lysine N-methyltransferase
2.1.1.60 calmodulin-lysine N-methyltransferase









(5R)-5-phosphohydroxy-L-lysine + H2O <=> (S)-2-amino-6-oxohexanoate + NH3 + phosphate 4.2.3.134 5-phosphooxy-L-lysine phospho-lyase

L-pipecolic_acid + FAD <=> FADH2 + (S)-2,3,4,5-tetrahydropyridine-2-carboxylate 1.5.99.3 L-pipecolate dehydrogenase

saccharopine + H2O + NAD+ <=> 2-oxoglutarate + L-lysine + NADH + H+ 1.5.1.7 saccharopine dehydrogenase (NAD+, L-lysine-forming)
1.5.1.8 saccharopine dehydrogenase (NADP+, L-lysine-forming)


5-hydroxylysine + GTP <=> H+ + (5R)-5-phosphohydroxy-L-lysine + GDP 2.7.1.81 hydroxylysine kinase

cadaverine + 2-oxoglutarate <=> 5-Aminopentanal + L-glutamate 2.6.1
2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.29 diamine transaminase
2.6.1.82 putrescine---2-oxoglutarate transaminase




5-Aminopentanal + NAD+ + H2O <=> 5-Aminopentanoate + NADH + H+ 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)


(S)-2-amino-6-oxohexanoate + NADP+ + H2O <=> L-2-aminoadipate + NADPH + H+ 1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase

(S)-2-amino-6-oxohexanoate + NAD+ + H2O <=> L-2-aminoadipate + NADH + H+ 1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase

N6,N6,N6-Trimethyl-L-lysine + 2-oxoglutarate + O2 <=> (3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2 1.14.11.8 trimethyllysine dioxygenase

4-N-trimethylaminobutyraldehyde + NAD+ + H2O <=> gamma-butyrobetaine + NADH + H+ 1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenase
1.2.1.8 betaine-aldehyde dehydrogenase



saccharopine + NADP+ + H2O <=> H+ + L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH 1.5.1.10 saccharopine dehydrogenase (NADP+, L-glutamate-forming)

glutaryl-CoA + flavin <=> crotonyl-CoA + CO2 + reduced_flavodoxin 1.3.8.6 glutaryl-CoA dehydrogenase (ETF)

L-2-aminoadipate + 2-oxoglutarate <=> L-glutamate + 2-oxoadipate 2.6.1.39 2-aminoadipate transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase


5-Aminopentanoate + 2-oxoglutarate <=> L-glutamate + 5-Oxopentanoate 2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2 alanine transaminase
2.6.1.48 5-aminovalerate transaminase



H+ + DELTA1-piperideine-2-carboxylate + H2O <=> 6-Amino-2-oxohexanoate not assigned

4-N-trimethylaminobutyraldehyde + glycine <=> (3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine 4.1.2

N6,N6,N6-Trimethyl-L-lysine + 2 protein <=> Protein_N6,N6,N6-trimethyl-L-lysine + 2 H2O 3.4

L-lysine + O2 <=> 5-Aminopentanamide + CO2 + H2O 1.13.12.2 lysine 2-monooxygenase

L-pipecolic_acid + O2 <=> H+ + DELTA1-piperidine_6-carboxylate + H2O2 1.5.3.7 L-pipecolate oxidase

L-lysine + H2O + O2 <=> 6-Amino-2-oxohexanoate + NH3 + H2O2 1.13.12.2 lysine 2-monooxygenase
1.4.3.14 L-lysine oxidase
1.4.3.2 L-amino-acid oxidase
1.4.3.25 L-arginine oxidase




butyryl-CoA + acetoacetate <=> Butyrate + acetoacetyl-CoA 2.8.3.9 butyrate---acetoacetate CoA-transferase

L-pipecolic_acid + NADP+ <=> DELTA1-piperideine-2-carboxylate + NADPH + H+ 1.5.1.1 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
1.5.1.21 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)
1.5.1.25 thiomorpholine-carboxylate dehydrogenase
1.5.1.49 1-pyrroline-2-carboxylate reductase [NAD(P)H]




D-2,5-diaminohexanoate + H2O + NADP+ <=> 2-Amino-5-oxohexanoate + NH3 + NADPH + H+ 1.4.1.12 2,4-diaminopentanoate dehydrogenase

(S)-2-hydroxyglutarate + a_quinone <=> 2-oxoglutarate + a_quinol 1.1.5.13 (S)-2-hydroxyglutarate dehydrogenase

saccharopine + H2O + NADP+ <=> L-lysine + 2-oxoglutarate + NADPH + H+ 1.5.1.8 saccharopine dehydrogenase (NADP+, L-lysine-forming)

L-lysine <=> D-Lysine 5.1.1.1 alanine racemase
5.1.1.10 amino-acid racemase
5.1.1.5 lysine racemase
5.1.1.9 arginine racemase




5-acetamidopentanoate + H2O <=> 5-Aminopentanoate + acetate 3.5.1
3.5.1.63 4-acetamidobutyrate deacetylase


N6-acetyl-L-lysine + 2-oxoglutarate <=> L-glutamate + 6-(acetylamino)-2-oxohexanoic_acid 2.6.1
2.6.1.36 L-lysine 6-transaminase
2.6.1.65 N6-acetyl-beta-lysine transaminase
2.6.1.67 2-aminohexanoate transaminase




L-pipecolic_acid + NAD+ <=> DELTA1-piperideine-2-carboxylate + NADH + H+ 1.5.1
1.5.1.1 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
1.5.1.21 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)
1.5.1.49 1-pyrroline-2-carboxylate reductase [NAD(P)H]
1.5.1.B5





L-lysine + acetyl_phosphate <=> H+ + phosphate + N6-acetyl-L-lysine 2.3.1.32 lysine N-acetyltransferase

saccharopine + H2O + NAD+ <=> L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+ 1.5.1.9 saccharopine dehydrogenase (NAD+, L-glutamate-forming)

L-beta-Lysine <=> L-erythro-3,5-diaminohexanoate 5.4.3.3 lysine 5,6-aminomutase
5.4.3.4 D-lysine 5,6-aminomutase


H2O + NADP+ + D-lysopine <=> H+ + NADPH + pyruvate + L-lysine 1.5.1.11 D-octopine dehydrogenase
1.5.1.16 D-lysopine dehydrogenase


5-Aminopentanamide + H2O <=> 5-Aminopentanoate + NH3 3.5.1.30 5-aminopentanamidase

Glutarate + 2-oxoglutarate + O2 <=> (S)-2-hydroxyglutarate + succinate + CO2 1.14.11.64 glutarate dioxygenase

D-Lysine + a_2-oxo_carboxylate <=> 6-Amino-2-oxohexanoate + a_D-amino_acid 2.6.1.21 D-amino-acid transaminase

L-3-aminobutanoyl-CoA <=> NH3 + crotonyl-CoA 4.3.1.14 3-aminobutyryl-CoA ammonia-lyase

acetyl-CoA <=> acetoacetyl-CoA + CoA 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.38 [acyl-carrier-protein] S-acetyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase





S-adenosyl-L-methionine + Calmodulin <=> S-adenosyl-L-homocysteine + calmodulin_N6-methyl-L-lysine 2.1.1.127 [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase
2.1.1.354 [histone H3]-lysine4 N-trimethyltransferase
2.1.1.355 [histone H3]-lysine9 N-trimethyltransferase
2.1.1.356 [histone H3]-lysine27 N-trimethyltransferase
2.1.1.357 [histone H3]-lysine36 N-dimethyltransferase
2.1.1.359 [histone H3]-lysine36 N-trimethyltransferase
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
2.1.1.361 [histone H4]-lysine20 N-methyltransferase
2.1.1.362 [histone H4]-N-methyl-L-lysine20 N-methyltransferase
2.1.1.364 [histone H3]-lysine4 N-methyltransferase
2.1.1.367 [histone H3]-lysine9 N-methyltransferase
2.1.1.368 [histone H3]-lysine9 N-dimethyltransferase
2.1.1.369 [histone H3]-lysine27 N-methyltransferase
2.1.1.370 [histone H3]-lysine4 N-dimethyltransferase
2.1.1.371 [histone H3]-lysine27 N-dimethyltransferase
2.1.1.372 [histone H4]-lysine20 N-trimethyltransferase
2.1.1.43 histone-lysine N-methyltransferase
2.1.1.59 [cytochrome c]-lysine N-methyltransferase
2.1.1.60 calmodulin-lysine N-methyltransferase



















L-lysine + H+ <=> cadaverine + CO2 4.1.1.17 ornithine decarboxylase
4.1.1.18 lysine decarboxylase
4.1.1.19 arginine decarboxylase
4.1.1.50 adenosylmethionine decarboxylase
4.1.1.86 diaminobutyrate decarboxylase
4.1.1.B12






D-Lysine <=> D-2,5-diaminohexanoate 5.4.3.3 lysine 5,6-aminomutase
5.4.3.4 D-lysine 5,6-aminomutase


D-2,5-diaminohexanoate + H2O + NAD+ <=> 2-Amino-5-oxohexanoate + NH3 + NADH + H+ 1.4.1.12 2,4-diaminopentanoate dehydrogenase

UDP-galactose + (2S,5R)-_5-hydroxy-L-lysine-[procollagen] <=> UDP + procollagen_5-(D-galactosyloxy)-L-lysine 2.4.1.50 procollagen galactosyltransferase

2-oxoadipate + NAD+ + CoA <=> CO2 + NADH + glutaryl-CoA 1.2.1.ak
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
1.8.1.4 dihydrolipoyl dehydrogenase
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase




5-Oxopentanoate + H2O + NAD+ <=> Glutarate + NADH + H+ 1.2.1.20 glutarate-semialdehyde dehydrogenase
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase


butyryl-CoA + NADP+ <=> crotonyl-CoA + NADPH + H+ 1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
1.3.1.44 trans-2-enoyl-CoA reductase (NAD+)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)
1.3.1.85 crotonyl-CoA carboxylase/reductase
1.3.1.86 crotonyl-CoA reductase
1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)








S-adenosyl-L-methionine + protein_N6-methyl-L-lysine <=> S-adenosyl-L-homocysteine + protein_N6,N6-dimethyl-L-lysine 2.1.1.354 [histone H3]-lysine4 N-trimethyltransferase
2.1.1.355 [histone H3]-lysine9 N-trimethyltransferase
2.1.1.356 [histone H3]-lysine27 N-trimethyltransferase
2.1.1.357 [histone H3]-lysine36 N-dimethyltransferase
2.1.1.359 [histone H3]-lysine36 N-trimethyltransferase
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
2.1.1.362 [histone H4]-N-methyl-L-lysine20 N-methyltransferase
2.1.1.368 [histone H3]-lysine9 N-dimethyltransferase
2.1.1.370 [histone H3]-lysine4 N-dimethyltransferase
2.1.1.371 [histone H3]-lysine27 N-dimethyltransferase
2.1.1.372 [histone H4]-lysine20 N-trimethyltransferase
2.1.1.59 [cytochrome c]-lysine N-methyltransferase
2.1.1.60 calmodulin-lysine N-methyltransferase













butyryl-CoA + NAD+ <=> crotonyl-CoA + NADH + H+ 1.3.1.44 trans-2-enoyl-CoA reductase (NAD+)
1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)


H2O + 6-(acetylamino)-2-oxohexanoic_acid + NAD+ <=> H+ + 5-acetamidopentanoate + NADH + CO2 1.1.1
1.2.4


(S)-5-amino-3-oxohexanoate + acetyl-CoA <=> L-3-aminobutanoyl-CoA + acetoacetate 2.3.1.247 3-keto-5-aminohexanoate cleavage enzyme

D-Lysine + H+ <=> cadaverine + CO2 4.1.1.116 D-ornithine/D-lysine decarboxylase
6707


CoA + Glutarate + ATP <=> glutaryl-CoA + phosphate + ADP 6.2.1.6 glutarate---CoA ligase

gamma-butyrobetaine + 2-oxoglutarate + O2 <=> L-carnitine + succinate + CO2 1.14.11.1 gamma-butyrobetaine dioxygenase

protein + 2-oxoglutarate + O2 <=> (2S,5R)-_5-hydroxy-L-lysine-[procollagen] + succinate + CO2 1.14.11.4 procollagen-lysine 5-dioxygenase

N6-acetyl-L-lysine + H2O <=> L-lysine + acetate 3.5.1.17 acyl-lysine deacylase

L-erythro-3,5-diaminohexanoate + NAD+ + H2O <=> H+ + (S)-5-amino-3-oxohexanoate + NH3 + NADH 1.4.1.11 L-erythro-3,5-diaminohexanoate dehydrogenase

(S)-3-hydroxybutyryl-CoA + NAD+ <=> acetoacetyl-CoA + NADH + H+ 1.1.1.178 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
1.1.1.36 acetoacetyl-CoA reductase



6-(acetylamino)-2-oxohexanoic_acid + H2O <=> acetate + 6-Amino-2-oxohexanoate 3.5.1.17 acyl-lysine deacylase

L-lysine <=> L-beta-Lysine 5.4.3.2 lysine 2,3-aminomutase

(S)-3-hydroxybutyryl-CoA <=> H2O + crotonyl-CoA 1.3.8.7 medium-chain acyl-CoA dehydrogenase
4.2.1.116 3-hydroxypropionyl-CoA dehydratase
4.2.1.150 short-chain-enoyl-CoA hydratase
4.2.1.17 enoyl-CoA hydratase




Visualization of the pathway